Search on: REPRESSOR PROTEINS 
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Descriptor English:   Repressor Proteins 
Descriptor Spanish:   Proteínas Represoras 
Descriptor Portuguese:   Proteínas Repressoras 
Synonyms English:   Lac Repressors
Repressor Molecules  
Tree Number:   D12.776.930.700
Definition English:   Proteins which are normally bound to the operator locus of an operon, thereby preventing transcription of the structural genes. In enzyme induction, the substrate of the inducible enzyme binds to the repressor protein, causing its release from the operator and freeing the structural genes for transcription. In enzyme repression, the end product of the enzyme sequence binds to the free repressor protein, the resulting complex then binds to the operator and prevents transcription of the structural genes. 
Indexing Annotation English:   transcription factors; /biosyn /drug eff /physiol permitted
History Note English:   91(79); was see under TRANSCRIPTION FACTORS 1979-90 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification CT contraindications
DU diagnostic use DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects SE secretion
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   12518 
Unique Identifier:   D012097 

Occurrence in VHL:
 

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